TY  - JOUR
PY  - 2012//
TI  - Depressive symptoms and their association with acute treatment outcome in first-episode schizophrenia patients: comparing treatment with risperidone and haloperidol
JO  - World journal of biological psychiatry
A1  - Riedel, Michael
A1  - Mayr, Andreas
A1  - Seemüller, Florian
A1  - Maier, Wolfgang
A1  - Klingberg, Stefan
A1  - Heuser, Isabella
A1  - Klosterkötter, Joachim
A1  - Gastpar, Markus
A1  - Schmitt, Andrea
A1  - Sauer, Heinrich
A1  - Schneider, Frank
A1  - Gaebel, Wolfgang
A1  - Jäger, Markus
A1  - Moller, Hans-Jurgen
A1  - Schennach-Wolff, Rebecca
SP  - 30
EP  - 38
VL  - 13
IS  - 1
N2  - OBJECTIVE: To evaluate depressive symptoms regarding their association with the acute outcome in first-episode schizophrenia comparing risperidone and haloperidol.  METHOD: A total of 274 patients were analysed within a double-blind randomized controlled trial and treated with risperidone or haloperidol. The patients were grouped according to their baseline HAMD-21 total score in a "depressed" (HAMD-21 ≥16) or "non-depressed" (HAMD-21 <16) patient subgroup. PANSS, HAMD-21, GAF, SOFAS and AIMS ratings were performed. Early response was defined as an initial 20% reduction of the PANSS total score from admission to week 2, response as an at least 50% reduction of the PANSS total score from admission to discharge and remission according to the consensus criteria.  RESULTS: A total of 124 patients were classified as depressive at baseline with 22 patients still being depressive at discharge. The depressed and non-depressed patients did not significantly differ regarding the treatment with risperidone and haloperidol (P = 0.2270). The depressive patients suffered from significantly more suicidal tendencies (P = 0.0165), had significantly less insight into their illness (P = 0.0152) and featured significantly worse functioning (P = 0.0066). Patients with depressive symptoms achieved remission significantly less often than non-depressed patients.  CONCLUSION: The importance of a specific and adequate treatment of depressive symptoms is highlighted.<p /> <p>Language: en</p>
LA  - en
SN  - 1562-2975
UR  - http://dx.doi.org/10.3109/15622975.2011.552633
ID  - ref1
ER  -