TY  - JOUR
PY  - 2011//
TI  - [Massive lamotrigine poisoning--case report]
JO  - Przeglad Lekarski
A1  - Kicka, Mariusz
A1  - Kłopotowski, Tomasz
A1  - Picheta, Sebastian
A1  - Bazylewicz, Anna
A1  - Miśkiewicz, Łukasz
SP  - 543
EP  - 545
VL  - 68
IS  - 8
N2  - Lamotrigine is a phenyltriazine derivative used as antiepileptic drug with pharmacological profile similar to phenytoin. It is chemically unrelated to the other antiepileptic drugs and mechanism of anticonvulsant action is that lamotrigine inhibits sodium channels, resulting in neuronal membrane stabilization and block of excitatory neurotransmitter release. Mean therapeutical dose of lamotrigine is 200 - 400 mg/day. Overdose experience with lamotrigine is limited. In severe cases of poisonings there were serious effects such as: coma, respiratory depression, recurrent seizures and intraventricular conduction disturbances. We report massive suicidal poisoning with lamotirigine unknown dose. Clinical course was severe--we observed deep coma, respiratory depression, epileptical state, ventricular disrhytmias, atrio-venticular heart block, cardiovascular shock, rhabdomyolysis and hypokalemia. There was ventricular fibrillation in course of poisoning. The patient was successfully resuscitated and discharged on 18 hospital day.<p /> <p>Language: pl</p>
LA  - pl
SN  - 0033-2240
UR  - http://dx.doi.org/
ID  - ref1
ER  -