TY  - JOUR
PY  - 2011//
TI  - Suicide inactivation of tyrosinase in its action on tetrahydropterines
JO  - Journal of enzyme inhibition and medicinal chemistry
A1  - Munoz-Munoz, Jose Luis
A1  - García-Molina, Francisco
A1  - Arribas, Enrique
A1  - García-Ruiz, Pedro Antonio
A1  - Tudela, José
A1  - García-Cánovas, Francisco
A1  - Rodriguez-Lopez, Jose Neptuno
SP  - 728
EP  - 733
VL  - 26
IS  - 5
N2  - Tetrahydrobiopterin (BH(4)), methyl-tetrahydropterin (MBH(4)) and dimethyl-tetrahydropterin (DMBH(4)) are oxidized by tyrosinase in a process during which the suicide inactivation of tyrosinase may occur. From the kinetic study of this process, [Formula: see text] (apparent maximum constant for the suicide inactivation), [Formula: see text] (Michaelis constant for the substrate) and r (number of turnovers that the enzyme makes before the inactivation) can be obtained. From the results obtained, it can be deduced that the velocity of the inactivation governed by ([Formula: see text]) and the potency of the same ([Formula: see text]) follow the order: BH(4) > MBH(4) > DMBH(4).<p /> <p>Language: en</p>
LA  - en
SN  - 1475-6366
UR  - http://dx.doi.org/10.3109/14756366.2010.548811
ID  - ref1
ER  -