TY  - JOUR
PY  - 2019//
TI  - Blonanserin suppresses impulsive action in rats
JO  - Journal of pharmacological sciences
A1  - Nishitani, Naoya
A1  - Sasamori, Hitomi
A1  - Ohmura, Yu
A1  - Yoshida, Takayuki
A1  - Yoshioka, Mitsuhiro
SP  - 127
EP  - 130
VL  - 141
IS  - 3
N2  - High impulsivity will increase the risk of criminal behavior, drug abuse, and suicide. We chose two drugs by following a strategy recently we proposed for identifying potential anti-impulsivity drugs, and examined the effects on impulsive action in rats by using a 3-choice serial reaction time task. We showed that the administration of blonanserin, an atypical antipsychotic, reduced impulsive actions in a U-shaped manner. 1-(2-Pyriidinyl)-piperazine, an active metabolite of buspirone or tandospirone, also slightly reduced impulsive actions, though it impaired motor functions. These results affirm the validity of our strategy, but require its refinement for developing anti-impulsivity drugs.<p /> <p>Language: en</p>
LA  - en
SN  - 1347-8613
UR  - http://dx.doi.org/10.1016/j.jphs.2019.09.013
ID  - ref1
ER  -