TY  - JOUR
PY  - 2019//
TI  - Incidence Rate and Predictors of Globus Pallidus Necrosis after Charcoal Burning Suicide
JO  - International journal of environmental research and public health
A1  - Ku, Chung-Hsuan
A1  - Huang, Wen-Hung
A1  - Hsu, Ching-Wei
A1  - Chen, Yu-Chin
A1  - Hou, Yi-Chou
A1  - Wang, I.-Kuan
A1  - Hong, Hsiang-Hsi
A1  - Wang, Yen-Li
A1  - Weng, Cheng-Hao
A1  - Yen, Tzung-Hai
SP  - e4426
EP  - e4426
VL  - 16
IS  - 22
N2  - OBJECTIVE: This study examined predictors of globus pallidus necrosis as there was a paucity of literature of globus pallidus necrosis resulted from carbon monoxide poisoning after charcoal burning suicide. <br><br>METHODS: A total of 67 patients who had attempted charcoal burning suicide were recruited and stratified into two subgroups based on either presence (n = 40) or absence (n = 27) of globus pallidus necrosis. Demographic, clinical, laboratory, and radiographic data were obtained for cross-sectional analysis. All patients were followed to investigate the risks for mortality. <br><br>RESULTS: The patients aged 36.8 ± 11.1 years (67.2%) were male. Patients with globus pallidus necrosis were younger (p = 0.044) and had less hypertension (p = 0.015) than patients without globus pallidus necrosis. Furthermore, patients with globus pallidus necrosis suffered from severer medical complications, i.e., fever (p = 0.008), acute myocardial injury (p = 0.022), acute rhabdomyolysis (p = 0.022), and neuropsychiatric symptoms (p < 0.001) than patients without globus pallidus necrosis. Moreover, patients with globus pallidus necrosis received less hyperbaric oxygen therapy than without necrosis (p = 0.024). Two patients (3.0%) died on arrival. In a multivariable regression model, it was revealed that acute myocardial injury (odds ratio 4.6, confidence interval 1.1-18.9, p = 0.034) and neuropsychiatric symptoms (odds ratio 8.0, confidence interval 2.0-31.4, p = 0.003), decreased blood bicarbonate level (odds ratio 0.8, confidence interval 0.7-1.0, p = 0.032), and younger age (odds ratio 0.9, confidence interval 0.9-1.0, p = 0.038) were significant predictors for globus pallidus necrosis. <br><br>CONCLUSION: Although patients who had attempted charcoal burning suicide had a low mortality rate (3.0%), globus pallidus necrosis was not uncommon (59.7%) in this population. Further studies are warranted.<p /> <p>Language: en</p>
LA  - en
SN  - 1661-7827
UR  - http://dx.doi.org/10.3390/ijerph16224426
ID  - ref1
ER  -