TY  - JOUR
PY  - 2019//
TI  - Interleukin-6 and Interleukin-10 in mood disorders: A population-based study
JO  - Psychiatry research
A1  - Wiener, Carolina David
A1  - Moreira, Fernanda Pedrotti
A1  - Portela, Luis Valmor
A1  - Strogulski, Nathan R.
A1  - Lara, Diogo R.
A1  - da Silva, Ricardo Azevedo
A1  - Souza, Luciano Dias de Mattos
A1  - Jansen, Karen
A1  - Oses, Jean Pierre
SP  - 685
EP  - 689
VL  - 273
IS  - 
N2  - OBJECTIVE: The aim of this study was to assess if cytokines levels (IL-6 and IL-10) are related to major depressive disorder (MDD) and bipolar disorder (BD), in a population-based study.  METHODS: This was a cross-sectional study population-based, involving 1037 people aged 18-35. MDD, BD, anxiety and suicide risk were assessed using the Mini International Neuropsychiatric Interview. Serum IL-6 and IL-10 were measured by ELISA using a commercial kit.  RESULTS: The total sample comprised 1034 young adults, being 14.4% with MDD and 13.7% with BD. MDD and BD groups showed significantly higher serum IL-6 levels (p ≤ 0.001) and IL-10 levels (p ≤ 0.001) when compared to healthy control group. No correlation was found between serum IL-6 and IL-10 levels in health control group (p = 0.830; r = -0.008), non-suicide risk (p = 0.337; r = 0.032) and non-anxiety disorder (p = 0.375; r = 0.031). Covariance analysis showed that mood disorders alone, increase both interleukin levels (IL-6, p = 0.019; and IL-10, p = 0.026), whilst the interaction of mood disorders and suicide risk or anxiety disorders did not.  CONCLUSION: Our results suggest that inflammatory dysregulation may be involved in the physiopathology of mood disorders and serum IL-6 and IL-10 levels are putative biomarkers for these disorders.<p /> <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/10.1016/j.psychres.2019.01.100
ID  - ref1
ER  -