TY  - JOUR
PY  - 2017//
TI  - Loperamide metabolite-induced cardiomyopathy and QTc prolongation
JO  - Clinical toxicology (Philadelphia, Pa.)
A1  - Bhatti, Zabeer
A1  - Norsworthy, Jessica
A1  - Szombathy, Tamas
SP  - 659
EP  - 661
VL  - 55
IS  - 7
N2  - Loperamide is an over-the-counter, peripherally acting, μ-opioid receptor agonist used for the treatment of diarrhea. In recent times users have found that at higher doses, loperamide crosses the blood-brain barrier and reaches central μ-receptors in the brain, leading to central opiate effects including euphoria and respiratory depression. We report a case of a 37-year-old female who attempted suicide with over 200 loperamide tablets. During her overdose, her QTc was significantly prolonged at >600 ms. Our case aims to add to the growing body of literature describing life-threatening ventricular arrhythmias associated with loperamide toxicity and further suggests that a metabolite of loperamide, desmethylloperamide, may play a role in the pathogenesis.<p /> <p>Language: en</p>
LA  - en
SN  - 1556-3650
UR  - http://dx.doi.org/10.1080/15563650.2017.1304555
ID  - ref1
ER  -