TY  - JOUR
PY  - 2017//
TI  - Severe Acute Valproic Acid Intoxication Successfully Treated with Liver Support Therapy
JO  - Basic and Clinical Pharmacology and Toxicology
A1  - Ge, Yongchun
A1  - Xu, Bin
A1  - Zhu, Shuhua
A1  - Li, Chuan
A1  - He, Qunpeng
A1  - Zhu, Tingting
A1  - Fan, Rong
A1  - Gong, Dehua
SP  - 368
EP  - 370
VL  - 121
IS  - 4
N2  - Valproic acid (VPA) is widely used for the treatment of epilepsy. However, its overdose can cause intoxication and could be life-threatening. Due to the lack of specific antidote and poorness of endogenous clearance, extracorporeal treatment for severe intoxication cases is indicated. Here, we report a case of severe intoxication of VPA which was successfully treated with liver support therapy. A previously healthy woman was admitted due to coma and hypotension after intentional ingestion of 20 g of sodium valproate. Her serum concentration of VPA measured on admission was 420.84 mg/L. In addition to standard therapy, she received two sessions of extracorporeal blood purification using a system based on fractionated plasma separation and adsorption mode integrated with continuous veno-venous haemofiltration (FPSA-CVVH), which is usually used for liver support therapy at our hospital. Her serum concentration of VPA decreased dramatically to 40.18 mg/L and her consciousness recovered completely within 24 hr after admission. Therefore, although haemodialysis has been reported to be effective in the treatment for VPA poisoning, FPSA-CVVH may provide an option for patients who require bedside therapy but have an unstable haemodynamic status or other conditions that result in inability to endure haemodialysis.<p /> <p>Language: en</p>
LA  - en
SN  - 1742-7835
UR  - http://dx.doi.org/10.1111/bcpt.12807
ID  - ref1
ER  -