TY  - JOUR
PY  - 2024//
TI  - Comparison of depression and suicide between dialysis and kidney transplant recipients in Korea: a nationwide population study
JO  - Clinical transplantation and research
A1  - Kang, Min Seok
A1  - Kim, Dong Young
A1  - Kim, Sung Hwa
A1  - Kim, Jae Seok
A1  - Yang, Jae Won
A1  - Han, Byoung Geun
A1  - Kang, Dae Ryong
A1  - Lee, Jinhee
A1  - Lee, Jun Young
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Kidney transplantation (KT) improves physical and psychological prognoses for patients with end-stage kidney disease (ESKD). However, few comparative studies have examined depression and suicide rates among patients with ESKD treated with dialysis versus KT. <br><br>METHODS: Data on 21,809 patients with ESKD were extracted from the Korean National Health Insurance Service database, extending from January 2002 to December 2018. These patients exhibited no history of depression or insomnia before starting renal replacement therapy. Outcomes were compared between dialysis and KT recipients using 1:2 propensity score matching (PSM). <br><br>RESULTS: Of the patients, 17,649 received dialysis (hemodialysis, 15,537; peritoneal dialysis, 2,112), while 4,160 underwent KT. Of those on dialysis, 45.04% (7,949) experienced insomnia, compared to 25.72% (1,070) of KT recipients (P<0.001). Depression was more frequent among dialysis recipients (22.77%, 4,019) than KT recipients (8.61%, 358; P<0.001). Additionally, those on dialysis had a higher incidence of suicide (0.19%, 33) than recipients of KT (0.12%, 5; P=0.047). After PSM, the hazard ratio (HR) for depression in patients on dialysis compared to KT recipients was 1.76 (95% confidence interval [CI], 1.56-1.99). In subgroup analysis, the relative likelihood of depression among dialysis recipients was particularly high for residents of urban areas (HR, 2.10; 95% CI, 1.80-2.44) and patients under 65 years old (HR, 1.82; 95% CI, 1.62-2.09). <br><br>CONCLUSIONS: KT recipients exhibit a lower suicide rate than patients on dialysis. Furthermore, KT is associated with a lower prevalence of depression among Korean patients with ESKD, particularly urban residents and individuals under 65 years old.<p />  <p>Language: en</p>
LA  - en
SN  - 3022-6783
UR  - http://dx.doi.org/10.4285/ctr.24.0004
ID  - ref1
ER  -