TY  - JOUR
PY  - 2024//
TI  - Prefrontal brain activity and self-injurious behavior in adolescents with major depressive disorder: a functional near-infrared spectroscopy (fNIRS) study
JO  - Journal of psychiatric research
A1  - Zhang, Yunshu
A1  - Li, Bing
A1  - Zhang, Lili
A1  - Cheng, Aobo
A1  - Long, Shuaiyu
A1  - Wang, Jie
A1  - Wen, Min
A1  - Li, Keqing
A1  - Liu, Chaomeng
SP  - 248
EP  - 253
VL  - 176
IS  - 
N2  - In clinical practice, accurately identifying self-injurious behavior among adolescents with major depressive disorder (MDD) is crucial for individualized treatment. This study aimed to examine the differences in prefrontal cortex activation using the functional near-infrared spectroscopy (fNIRS) during the verbal fluency task (VFT) assessment of adolescents with MDD and self-harm (SH) compared with those without SH. A total of 60 eligible patients were included for final analysis, with the SH group containing 36 participants, and the Non-SH group containing 24 participants. We found that right middle frontal gyrus (rMFG) was more activated in the SH group than that in the Non-SH group during the VFT assessments (z = -3.591, p = 0.004, FDR correction). The z-scores of beta values of rMFG exhibited a good discriminatory power with the area under the curve (AUC) in distinguishing the two groups (AUC = 0.775, p < 0.001). These findings reveal that the fNIRS-VFT paradigm may be a useful tool for discovering neurobiological differences among adolescents with MDD.<p />  <p>Language: en</p>
LA  - en
SN  - 0022-3956
UR  - http://dx.doi.org/10.1016/j.jpsychires.2024.06.001
ID  - ref1
ER  -