TY  - JOUR
PY  - 2024//
TI  - The Toronto Adolescent and Youth Cohort Study: study design and early data related to psychosis spectrum symptoms, functioning, and suicidality
JO  - Biological psychiatry: cognitive neuroscience and neuroimaging
A1  - Cleverley, Kristin
A1  - Foussias, George
A1  - Ameis, Stephanie H.
A1  - Courtney, Darren B.
A1  - Goldstein, Benjamin I.
A1  - Hawke, Lisa D.
A1  - Kozloff, Nicole
A1  - Quilty, Lena C.
A1  - Rotenberg, Martin
A1  - Wheeler, Anne L.
A1  - Andrade, Brendan F.
A1  - Aitken, Madison
A1  - Mahleka, Don
A1  - Jani, Melanie
A1  - Frayne, Margot
A1  - Wong, Jimmy K. Y.
A1  - Kelly, Rachel
A1  - Dickie, Erin W.
A1  - Felsky, Daniel
A1  - Haltigan, John D.
A1  - Lai, Meng-Chuan
A1  - Nikolova, Yuliya S.
A1  - Tempelaar, Wanda
A1  - Wang, Wei
A1  - Battaglia, Marco
A1  - Husain, Muhammad Omair
A1  - Kidd, Sean
A1  - Kurdyak, Paul
A1  - Levitan, Robert D.
A1  - Lewis, Stephen P.
A1  - Polillo, Alexia
A1  - Szatmari, Peter
A1  - van der Miesen, Anna I. R.
A1  - Ahmadzadasl, Masoud
A1  - Voineskos, Aristotle N.
A1  - TAY Cohort Study Team, 
SP  - 253
EP  - 264
VL  - 9
IS  - 3
N2  - BACKGROUND: Psychosis spectrum symptoms (PSSs) occur in a sizable percentage of youth and are associated with poorer cognitive performance, poorer functioning, and suicidality (i.e., suicidal thoughts and behaviors). PSSs may occur more frequently in youths already experiencing another mental illness, but the antecedents are not well known. The Toronto Adolescent and Youth (TAY) Cohort Study aims to characterize developmental trajectories in youths with mental illness and understand associations with PSSs, functioning, and suicidality.     METHODS: The TAY Cohort Study is a longitudinal cohort study that aims to assess 1500 youths (age 11-24 years) presenting to tertiary care. In this article, we describe the extensive diagnostic and clinical characterization of psychopathology, substance use, functioning, suicidality, and health service utilization in these youths, with follow-up every 6 months over 5 years, including early baseline data.     RESULTS: A total of 417 participants were enrolled between May 4, 2021, and February 2, 2023. Participants met diagnostic criteria for an average of 3.5 psychiatric diagnoses, most frequently anxiety and depressive disorders. Forty-nine percent of participants met a pre-established threshold for PSSs and exhibited higher rates of functional impairment, internalizing and externalizing symptoms, and suicidality than participants without PSSs.     CONCLUSIONS: Initial findings from the TAY Cohort Study demonstrate the feasibility of extensive clinical phenotyping in youths who are seeking help for mental health problems. PSS prevalence is much higher than in community-based studies. Our early data support the critical need to better understand longitudinal trajectories of clinical youth cohorts in relation to psychosis risk, functioning, and suicidality.<p />  <p>Language: en</p>
LA  - en
SN  - 2451-9030
UR  - http://dx.doi.org/10.1016/j.bpsc.2023.10.011
ID  - ref1
ER  -