TY  - JOUR
PY  - 2024//
TI  - Traumatic brain injury and cognitive change over 30 years among community-dwelling older adults
JO  - Alzheimer's and dementia
A1  - Schneider, Andrea L. C.
A1  - Pike, James R.
A1  - Elser, Holly
A1  - Coresh, Josef
A1  - Mosley, Thomas H.
A1  - Diaz-Arrastia, Ramon
A1  - Gottesman, Rebecca F.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - INTRODUCTION: There is limited evidence regarding the rate of long-term cognitive decline after traumatic brain injury (TBI) among older adults. <br><br>METHODS: In this prospective cohort study, time-varying TBI was defined by self-report and International Classification of Disease diagnostic codes. Cognitive testing was performed at five visits over 30 years and scores were combined into a global cognition factor score. Adjusted linear mixed-effects models estimated the association of TBI with cognitive change. <br><br>RESULTS: A total of 11,701 Atherosclerosis Risk in Communities (ARIC) Study participants (mean baseline age 58 years, 58% female, 25% Black) without TBI at baseline were included. Over follow-up, 18% experienced TBI. The adjusted average decline in cognition per decade (standard deviation units) was more than twice as fast among individuals with ≥ 2 incident TBIs (
LA  - en
SN  - 1552-5260
UR  - http://dx.doi.org/10.1002/alz.14104
ID  - ref1
ER  -