TY - JOUR
PY - 2024//
TI - A smartphone app-based intervention combined with face-to-face sessions for alcohol dependence at internal medicine clinics: a randomized controlled trial
JO - General hospital psychiatry
A1 - Miyake, Nozomi
A1 - So, Ryuhei
A1 - Kariyama, Kazuya
A1 - Itagaki, Yukie
A1 - Yamagishi, Takahiro
A1 - Wakuta, Akiko
A1 - Nishimura, Mamoru
A1 - Murakami, Shiho
A1 - Ogawa, Michihiro
A1 - Takebayashi, Yoshitake
A1 - Sunami, Takashi
A1 - Yumoto, Yosuke
A1 - Ito, Mitsuru
A1 - Maesato, Hitoshi
A1 - Matsushita, Sachio
A1 - Nouso, Kazuhiro
SP - 68
EP - 75
VL - 90
IS -
N2 - BACKGROUND: Addressing the limited access to treatments for alcohol dependence, we developed ALM-002, a therapeutic application to be "prescribed" for non-abstinence-oriented treatment in internal medicine settings. Our objective was to preliminarily assess the efficacy and safety of ALM-002.
METHODS: In a multicenter, open-label randomized controlled trial, participants aged ≥20 with alcohol dependence and daily alcohol consumption exceeding 60 g for men and 40 g for women, without severe complications, were randomly assigned to either the intervention group using ALM-002 or the treatment-as-usual control group. Participant in both groups received individual face-to-face sessions by physicians at weeks 0, 4, 8, and 12. The primary endpoint was the change in heavy drinking days (HDDs) from week 0 to week 12. A mixed model for repeated measures was employed.
RESULTS: We enrolled 43 participants: 22 in the intervention group and 21 in the control group. A significant reduction in HDDs every 4 weeks from week 0 to week 12 was observed, with a between-group difference of -6.99 days (95% CI: -12.4 to -1.6 days, standardized mean difference: -0.80).
CONCLUSIONS: These results indicate the potential of ALM-002 as a viable treatment for alcohol dependence. Further studies are needed to evaluate the clinical potential of ALM-002. Language: en
LA - en
SN - 0163-8343
UR - http://dx.doi.org/10.1016/j.genhosppsych.2024.07.003
ID - ref1
ER -