TY - JOUR PY - 2024// TI - Bad habits-good goals? Meta-analysis and translation of the habit construct to alcoholism JO - Translational psychiatry A1 - Giannone, F. A1 - Ebrahimi, C. A1 - Endrass, T. A1 - Hansson, A. C. A1 - Schlagenhauf, F. A1 - Sommer, W. H. SP - e298 EP - e298 VL - 14 IS - 1 N2 - Excessive alcohol consumption remains a global public health crisis, with millions suffering from alcohol use disorder (AUD, or simply "alcoholism"), leading to significantly reduced life expectancy. This review examines the interplay between habitual and goal-directed behaviors and the associated neurobiological changes induced by chronic alcohol exposure. Contrary to a strict habit-goal dichotomy, our meta-analysis of the published animal experiments combined with a review of human studies reveals a nuanced transition between these behavioral control systems, emphasizing the need for refined terminology to capture the probabilistic nature of decision biases in individuals with a history of chronic alcohol exposure. Furthermore, we distinguish habitual responding from compulsivity, viewing them as separate entities with diverse roles throughout the stages of the addiction cycle. By addressing species-specific differences and translational challenges in habit research, we provide insights to enhance future investigations and inform strategies for combatting AUD.

Language: en

LA - en SN - 2158-3188 UR - http://dx.doi.org/10.1038/s41398-024-02965-1 ID - ref1 ER -