TY  - JOUR
PY  - 2024//
TI  - Neural basis of agitated behaviors in patients with amnestic mild cognitive impairment and Alzheimer's disease
JO  - Journal of Alzheimer's disease
A1  - Kashibayashi, Tetsuo
A1  - Kanemoto, Hideki
A1  - Takahashi, Ryuichi
A1  - Fujito, Ryoko
A1  - Chadani, Yoshihiro
A1  - Tagai, Kenji
A1  - Shinagawa, Shunichiro
A1  - Ishii, Kazunari
A1  - Ikeda, Manabu
A1  - Kazui, Hiroaki
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Aggression, a common symptom of Alzheimer's disease (AD), can impose a significant burden on caregivers, necessitating early institutionalization. <br><br>OBJECTIVE: The current study examined the neural basis of aggression and its expression mechanism, to advance the development of effective treatment strategies for aggression in patients with AD. <br><br>METHODS: The study sample included 257 patients; 180 were diagnosed with AD and 77 with amnestic mild cognitive impairment (aMCI). Factor analysis of the neuropsychiatric inventory (NPI) aggression scores was performed, and the correlation between each factor and cerebral blood flow (CBF) was examined via diagnosis of AD or aMCI using statistical parametric mapping. <br><br>RESULTS: Refusal of care was correlated with reduced CBF in the right hippocampus of patients with AD while no specific related regions could be identified in patients with aMCI. Violent behavior was associated with decreased CBF in the right temporal pole and medial frontal lobe of patients with AD and aMCI. <br><br>CONCLUSIONS: These findings suggest that aggression, measured using NPI includes two distinct symptoms, refusal of care and violent behavior, having different underlying neural bases.<p />  <p>Language: en</p>
LA  - en
SN  - 1387-2877
UR  - http://dx.doi.org/10.3233/JAD-240256
ID  - ref1
ER  -