TY  - JOUR
PY  - 2024//
TI  - Spider and scorpion knottins targeting voltage-gated sodium ion channels in pain signaling
JO  - Biochemical pharmacology
A1  - Wang, Xiting
A1  - Luo, Huan
A1  - Peng, Xiaozhen
A1  - Chen, Jinjun
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - In sensory neurons that transmit pain signals, whether acute or chronic, voltage-gated sodium channels (VGSCs) are crucial for regulating excitability. Na(V)1.1, Na(V)1.3, Na(V)1.6, Na(V)1.7, Na(V)1.8, and Na(V)1.9 have been demonstrated and defined their functional roles in pain signaling based on their biophysical properties and distinct patterns of expression in each subtype of sensory neurons. Scorpions and spiders are traditional Chinese medicinal materials, belonging to the arachnid class. Most of the studied species of them have evolved venom peptides that exhibit a wide variety of knottins specifically targeting VGSCs with subtype selectivity and conformational specificity. This review provides an overview on the exquisite knottins from scorpion and spider venoms targeting pain-related Na(V) channels, describing the sequences and the structural features as well as molecular determinants that influence their selectivity on special subtype and at particular conformation, with an aim for the development of novel research tools on Na(V) channels and analgesics with minimal adverse effects.<p />  <p>Language: en</p>
LA  - en
SN  - 0006-2952
UR  - http://dx.doi.org/10.1016/j.bcp.2024.116465
ID  - ref1
ER  -