TY  - JOUR
PY  - 2024//
TI  - Impact of childhood maltreatment on aging: a comprehensive Mendelian randomization analysis of multiple age-related biomarkers
JO  - Clinical epigenetics
A1  - Zhang, Zheng
A1  - Ren, Hao
A1  - Han, Rong
A1  - Li, Qiyin
A1  - Yu, Jiangyou
A1  - Zhao, Yuan
A1  - Tang, Liwei
A1  - Peng, Yadong
A1  - Liu, Ying
A1  - Gan, Cheng
A1  - Liu, Keyi
A1  - Luo, Qinghua
A1  - Qiu, Haitang
A1  - Jiang, Chenggang
SP  - e103
EP  - e103
VL  - 16
IS  - 1
N2  - BACKGROUND: Childhood maltreatment (CM) is linked to long-term adverse health outcomes, including accelerated biological aging and cognitive decline. This study investigates the relationship between CM and various aging biomarkers: telomere length, facial aging, intrinsic epigenetic age acceleration (IEAA), GrimAge, HannumAge, PhenoAge, frailty index, and cognitive performance. <br><br>METHODS: We conducted a Mendelian randomization (MR) study using published GWAS summary statistics. Aging biomarkers included telomere length (qPCR), facial aging (subjective evaluation), and epigenetic age markers (HannumAge, IEAA, GrimAge, PhenoAge). The frailty index was calculated from clinical assessments, and cognitive performance was evaluated with standardized tests. Analyses included Inverse-Variance Weighted (IVW), MR Egger, and Weighted Median (WM) methods, adjusted for multiple comparisons. <br><br>RESULTS: CM was significantly associated with shorter telomere length (IVW: β = - 0.1, 95% CI - 0.18 to - 0.02, pFDR = 0.032) and increased HannumAge (IVW: β = 1.33, 95% CI 0.36 to 2.3, pFDR = 0.028), GrimAge (IVW: β = 1.19, 95% CI 0.19 to 2.2, pFDR = 0.040), and PhenoAge (IVW: β = 1.4, 95% CI 0.12 to 2.68, pFDR = 0.053). A significant association was also found with the frailty index (IVW: β = 0.31, 95% CI 0.13 to 0.49, pFDR = 0.006). No significant associations were found with facial aging, IEAA, or cognitive performance. <br><br>CONCLUSIONS: CM is linked to accelerated biological aging, shown by shorter telomere length and increased epigenetic aging markers. CM was also associated with increased frailty, highlighting the need for early interventions to mitigate long-term effects. Further research should explore mechanisms and prevention strategies.<p />  <p>Language: en</p>
LA  - en
SN  - 1868-7075
UR  - http://dx.doi.org/10.1186/s13148-024-01720-z
ID  - ref1
ER  -