TY  - JOUR
PY  - 2024//
TI  - IN esketamine and IV ketamine: results of a multi-site observational study assessing the effectiveness and tolerability of two novel therapies for treatment-resistant depression
JO  - Psychiatry research
A1  - Gutierrez, Gilmar
A1  - Swainson, Jennifer
A1  - Ravindran, Nisha
A1  - Lam, Raymond W.
A1  - Giacobbe, Peter
A1  - Karthikeyan, Ganapathy
A1  - Kowara, Annette
A1  - Do, André
A1  - Baskaran, Anusha
A1  - Nestor, Sean Michael
A1  - Kang, Melody J. Y.
A1  - Biorac, Aleksandar
A1  - Vazquez, Gustavo
SP  - e116125
EP  - e116125
VL  - 340
IS  - 
N2  - Intravenous (IV) ketamine and intranasal (IN) esketamine are novel therapies to manage treatment resistant depression within major depressive disorder (MDD-TRD). This is a multi-site observational study aiming to assess the real-world effectiveness and tolerability of these novel therapies in the management of MDD-TRD. 53 patients were referred to receive IV ketamine (n = 26, 69.23 % female, 52.81 ± 14.33 years old) or IN esketamine (n = 27, 51.85 % female, 43.93 ± 13.57 years old). Treatment effectiveness was assessed using the Montgomery and Åsberg Depression Rating Scale (MADRS) for depression severity and item 10 of the MADRS for suicidal ideation (SI). Tolerability was assessed by systematically tracking side effects and depersonalization using the 6-item Clinician administered dissociative symptom scale (CADSS-6). The data was analyzed using descriptive statistics, risk ratio and effect size. Both IV ketamine and IN esketamine significantly reduced depressive symptoms and suicidal ideation by treatment endpoint. Patients receiving IN esketamine, and patients receiving IV ketamine had a similar risk of developing side effects. All side effects reported were mild and transient. These results suggested that both IV ketamine and IN esketamine are effective in the management of depressive symptoms and were well tolerated. Therefore, the results of this study could serve to inform clinical practice.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/10.1016/j.psychres.2024.116125
ID  - ref1
ER  -