TY  - JOUR
PY  - 2024//
TI  - White matter damage and degeneration in traumatic brain injury
JO  - Trends in neurosciences
A1  - Armstrong, Regina C.
A1  - Sullivan, Genevieve M.
A1  - Perl, Daniel P.
A1  - Rosarda, Jessica D.
A1  - Radomski, Kryslaine L.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Traumatic brain injury (TBI) is a complex condition that can resolve over time but all too often leads to persistent symptoms, and the risk of poor patient outcomes increases with aging. TBI damages neurons and long axons within white matter tracts that are critical for communication between brain regions; this causes slowed information processing and neuronal circuit dysfunction. This review focuses on white matter injury after TBI and the multifactorial processes that underlie white matter damage, potential for recovery, and progression of degeneration. A multiscale perspective across clinical and preclinical advances is presented to encourage interdisciplinary insights from whole-brain neuroimaging of white matter tracts down to cellular and molecular responses of axons, myelin, and glial cells within white matter tissue.<p />  <p>Language: en</p>
LA  - en
SN  - 0166-2236
UR  - http://dx.doi.org/10.1016/j.tins.2024.07.003
ID  - ref1
ER  -