TY  - JOUR
PY  - 1955//
TI  - Psychosis apparently produced by reserpine
JO  - Journal of the American Medical Association
A1  - Schroeder, Henry A.
A1  - Perry, H. Mitchell, Jr.
SP  - 839
EP  - 840
VL  - 159
IS  - 9
N2  - The use of reserpine has become widespread, both for its tranquilizing effect in hypertension1 and its curiously unexplained action in schizophrenic reactions and other psychotic and psychoneurotic states.2 The fact that a yohimbine-like drug will act upon specific functions of the brain, probably on the hypothalamus or its connections, has opened the way to investigations on the chemical disorders of cerebral metabolism leading to functional disturbances. Reserpine and its chemical analogues are said to be safe and free from serious side-effects. Because psychoses developed in five individuals taking this drug, with slow recovery after withdrawal, and because nervousness, insomnia, and agitation have appeared in others, we considered it advisable to call attention to such reactions.A 60-year-old bookkeeper had exhibited asymptomatic hypertension for at least two years. There had been no episodes of overt psychosis or neurosis during his lifetime. His blood pressure...   Keywords: Suicide<p />
LA  - en
SN  - 0002-9955
UR  - http://dx.doi.org/10.1001/jama.1955.02960260009003
ID  - ref1
ER  -