TY  - JOUR
PY  - 2009//
TI  - A proton magnetic spectroscopy research on hippocampus metabolisms in people with suicide-attempted depressions
JO  - Sichuan Da Xue Xue Bao Yi Xue Ban
A1  - Li, Jiang
A1  - Kuang, Wei-Hong
A1  - Zou, Ke
A1  - Deng, Wenbin
A1  - Li, Tianhong
A1  - Gong, Qi-Yong
A1  - Sun, Xue-Li
SP  - 59
EP  - 62
VL  - 40
IS  - 1
N2  - OBJECTIVE: To investigate the metabolic features of hippocampus in people with suicide-attempted depressions. METHODS: Proton resonance spectroscopy (1H-MRS) was performed on the bilateral hippocampi of 24 patients with suicide-attempted depressions and 24 healthy people. The ratios of N-acetylasparte(NAA)/creatine (Cr), choline(Cho)/Cr and myoinositol(mI)/Cr were calculated and used as markers reflecting the metabolic levels of NAA, Cho and mI. The differences between the patients with suicide-attempted depressions and the healthy people were analyzed. The left hippocampus was also compared with the right to determine the asymmetry of the hippocampus metabolic. RESULTS: The ratio of NAA/Cr in the left hippocampus of the patients with suicide-attempted depressions was significantly less than that of the healthy control (P < 0.05). The ratio of NAA/Cr in the left hippocampus was significantly greater than in the right hippocampus of the healthy control (P < 0.05). However, the left-right deference of the ratio of NAA/Cr disappeared in the patients with suicide-attempted depressions. There was an asymmetry between the left and right hippocampi in the healthy people (P < 0.05), but not in the patients with suicide-attempted depressions (P > 0.05). No correlations between the metabolic markers and the course of disease, number of episodes and HAMD17 scores were found in the patients with suicide-attempted depressions (P > 0.05). CONCLUSION: There is a decrease of metabolite in the left hippocampus of patients with suicide-attempted depressions. The asymmetry of the bilateral hippocampi disappears in the patients with suicide-attempted depressions.<p />  <p>Language: zh</p>
LA  - zh
SN  - 1672-173X
UR  - http://dx.doi.org/
ID  - ref1
ER  -