TY - JOUR PY - 2009// TI - Alterations in Brain Serotonin Synthesis in Male Alcoholics Measured Using Positron Emission Tomography JO - Alcoholism: clinical and experimental research A1 - Nishikawa, Masami A1 - Diksic, Mirko A1 - Sakai, Yojiro A1 - Kumano, Hiroaki A1 - Charney, Dara A1 - Palacios‐Boix, Jorge A1 - Negrete, Juan A1 - Gill, Kathryn SP - 233 EP - 239 VL - 33 IS - 2 N2 - Background:  A consistent association between low endogenous 5HT function and high alcohol preference has been observed, and a number of serotonergic manipulations (uptake blockers, agonists) alter alcohol consumption in animals and humans. Studies have also shown an inverse relationship between alcohol use and cerebrospinal fluid levels of serotonin metabolites, suggesting that chronic alcohol consumption produces alterations in serotonin synthesis or release.

LA - SN - 0145-6008 UR - http://dx.doi.org/10.1111/j.1530-0277.2008.00820.x ID - ref1 ER -