TY - JOUR PY - 1994// TI - Biphasic time-course of serum concentrations of clomipramine and desmethylclomipramine after a near-fatal overdose JO - Veterinary and human toxicology A1 - Dale, O. A1 - Hole, A. SP - 309 EP - 310 VL - 36 IS - 4 N2 - A 27-y-old male was admitted deeply comatosed 5-6 h after taking approximately 15 g clomipramine. The prominent feature of the case was a biphasic course of clomipramine and desmethylclomipramine serum concentrations, possibly caused by delayed drug absorption. Clinically, 2 serious episodes requiring mechanical ventilation and aggressive pressor agent infusions occurred as the serum concentrations declined. However, the severe adult respiratory distress syndrome--related inflammatory process that required 4 w of intensive care may also be an explanation, although blood cultures were negative and neither liver nor renal functions were severely compromised.

Language: en

LA - en SN - 0145-6296 UR - http://dx.doi.org/ ID - ref1 ER -