TY - JOUR PY - 2013// TI - Follow-up study of two-year-olds born at very low gestational age in Estonia JO - Acta paediatrica A1 - Toome, Liis A1 - Varendi, Heili A1 - Männamaa, Mairi A1 - Vals, Mari-Anne A1 - Tänavsuu, Triinu A1 - Kolk, Anneli SP - 300 EP - 307 VL - 102 IS - 3 N2 - AIM: To study very low gestational age (VLGA, <32 weeks) infants at two years of age and to identify the predictors of adverse outcomes. METHODS: A population-based cohort of 155 surviving VLGA infants born in Estonia in 2007 was followed up and compared with a matched full-term control group. A logistic regression model was used to test associations between risk factors and adverse outcomes. RESULTS: No impairment was found in 60% of the VLGA infants. Neurodevelopmental impairment was noted in 12% of VLGA infants, with 8% of the infants affected by cerebral palsy without independent walking, 5% with cognitive delay, 10% with language delay, and 1% with hearing impairment. The differences between preterm and full-term infants in terms of the mean Cognitive, Language, and Motor Composite Scores assessed using the Bayley-III scales were in excess of 0.5 SD. Somatic growth delay was a significant problem among preterm infants. The existence of severe neonatal cerebral lesions was the most significant predictor of adverse outcomes. CONCLUSION: In all domains studied, adverse conditions were more prevalent among VLGA infants than among the full-term control group. Efforts to reduce neonatal morbidity in preterm infants should be a key priority for health care in Estonia. ©2012 The Author(s)/Acta Paediatrica ©2012 Foundation Acta Paediatrica.

Language: en

LA - en SN - 0803-5253 UR - http://dx.doi.org/10.1111/apa.12091 ID - ref1 ER -