TY - JOUR PY - 2013// TI - GABA receptors, alcohol dependence and criminal behavior JO - Journal of forensic sciences A1 - Terranova, Claudio A1 - Tucci, Marianna A1 - Sartore, Daniela A1 - Cavarzeran, Fabiano A1 - Di Pietra, Laura A1 - Barzon, Luisa A1 - Palù, Giorgio A1 - Ferrara, Santo D. SP - 1227 EP - 1232 VL - 58 IS - 5 N2 - The aim of this study was to analyze the connection between alcohol dependence and criminal behavior by an integrated genetic-environmental approach. The research, structured as a case-control study, examined 186 alcohol-dependent males; group 1 (N = 47 convicted subjects) was compared with group 2 (N = 139 no previous criminal records). Genetic results were innovative, highlighting differences in genotype distribution (p = 0.0067) in group 1 for single-nucleotide polymorphism rs 3780428, located in the intronic region of subunit 2 of the GABA B receptor gene (GABBR2). Some environmental factors (e.g., grade repetition) were associated with criminal behavior; others (e.g., attendance at Alcoholics Anonymous) were inversely related to convictions. The concomitant presence of the genetic and environmental factors found to be associated with the condition of alcohol-dependent inmate showed a 4-fold increase in the risk of antisocial behavior. The results need to be replicated on a larger population to develop new preventive and therapeutic proposals.

Language: en

LA - en SN - 0022-1198 UR - http://dx.doi.org/10.1111/1556-4029.12201 ID - ref1 ER -