TY - JOUR PY - 2019// TI - Ribosomal DNA transcription in prefrontal pyramidal neurons is decreased in suicide JO - European archives of psychiatry and clinical neuroscience A1 - Krzyżanowska, Marta A1 - Steiner, Johann A1 - Pieśniak, Dorota A1 - Karnecki, Karol A1 - Kaliszan, Michał A1 - Wiergowski, Marek A1 - Rębała, Krzysztof A1 - Brisch, Ralf A1 - Braun, Katharina A1 - Jankowski, Zbigniew A1 - Kosmowska, Monika A1 - Chociej, Joanna A1 - Gos, Tomasz SP - ePub EP - ePub VL - ePub IS - ePub N2 - Prefrontal cortical regions, which are crucial for the regulation of emotionally influenced behaviour, play most probably a dominant role in the pathogenesis of suicide. The study was carried out on paraffin-embedded brain tissue blocks containing specimens from the anterior cingulate cortex (dorsal and ventral parts), the orbitofrontal cortex, and the dorsolateral cortex obtained from 23 suicide completers (predominantly violent) with unknown psychiatric diagnosis and 25 non-suicidal controls. The transcriptional activity of ribosomal DNA (rDNA) as a surrogate marker of protein biosynthesis was evaluated separately in layers III and V pyramidal neurons in regions of interest (ROIs) mentioned above by the AgNOR silver staining method bilaterally. The overall statistical analysis revealed a decrease of AgNOR area suggestive of attenuated rDNA activity in suicide victims versus controls, particularly in male subjects. Further ROI-specific post-hoc analyses revealed decreases of the median AgNOR area in suicides compared to non-suicides in all 16 ROIs. However, this effect was only significant in the layer V pyramidal neurons of the right ventral anterior cingulate cortex. Our findings suggest that decreased rDNA transcription in prefrontal pyramidal neurons plays possibly an important role in suicide pathogenesis.

Language: en

LA - en SN - 0940-1334 UR - http://dx.doi.org/10.1007/s00406-019-00996-0 ID - ref1 ER -