Citation

Bedin M, Colodel EM, Giugliani R, Zlotwski P, Cruz CE, Driemeier D. Toxicon 2009; ePub(ePub): ePub.

Affiliation

Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos, 2350, Servi o de Genetica Medica. Bom Fim 90035-903, Porto Alegre-RS, Brasil.

Copyright

(Copyright © 2009, Elsevier Publishing)

DOI

10.1016/j.toxicon.2008.12.024

PMID

19470349

Abstract

Poisoning by Sida carpinifolia belongs to a group of plant-induced phenotype which resembles lysosomal storage diseases. Saanen goats were fed aerial parts of green S. carpinifolia for up to 3 months. Concentrates complemented the nutritional requirements. Urine and blood samples were collected for oligosaccharide study (by thin layer chromatography-TLC) and hemogram analysis, respectively. Abnormal excretion of oligosaccharides was observed from the 2(nd) day of S. carpinifolia ingestion until one day after withdrawal of the plant from the diet. There were no changes in hemogram. Clinical signs were typical of poisoning caused by plants of this group and were seen from the 37(th) day on Sida carpinifolia diet until seven days after withdrawal of the plant, when signs gradually became scarce and less evident. Results presented here suggest that detection of urinary oligosaccharides by TLC may be an useful method to assess swainsonine-containing plants exposure or an early diagnostic tool for poisoning by these plants.

Language: en