Citation

do Prado-Lima PA, Kristensen CH, Bacaltchuck J. J. Clin. Pharm. Ther. 2006; 31(2): 193-196.

Affiliation

Behavioral Neurobiology Research Group-- Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil. paspl@uol.com.br

Copyright

(Copyright © 2006, John Wiley and Sons)

DOI

10.1111/j.1365-2710.2006.00716.x

PMID

16635055

Abstract

We report on a woman with borderline personality disorder and a history of childhood trauma that showed significant clinical response with low dosage of topiramate. We propose that topiramate changed some of the main features of this disorder, such as catastrophic reaction to real or imaginary abandonment or rejection, improving adaptive functioning. We hypothesize that topiramate might facilitate memory extinction, therefore decreasing emotional and behavioural reactivity.

Language: en