Citation

Edmunds M, Sheehan TM, Van't Hoff W. J. Toxicol. Clin. Toxicol. 1986; 24(3): 245-255.

Erratum On

J Toxicol Clin Toxicol 1986;24(5):461

Copyright

(Copyright © 1986, Marcel Dekker)

DOI

unavailable

PMID

3723649

Abstract

The successful supportive management of an acute strychnine ingestion is described; clinical and biochemical findings are reported. A gas chromatographic assay for serum strychnine has been applied to the analysis of 19 serial blood samples. Four hours post ingestion, the serum strychnine concentration was 1.6 mg/L. This declined with T 1/2 corrected. of 10 hours over a period of 50 hours. First order kinetics are indicated. Management of strychnine poisoning in general is discussed in the light of this case and the limited knowledge of the pharmacokinetics of the alkaloid in man.

Language: en