Citation

Rao V, Munro CA, Rosenberg P, Ward J, Bertrand M, Degoankar M, Horská A, Pham D, Yousem DM, Barker PB. J. Neuropsychiatry Clin. Neurosci. 2010; 22(2): 231-235.

Affiliation

Division of Geriatric Psychiatry & Neuropsychiatry, Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA. vrao@jhmi.edu

Copyright

(Copyright © 2010, American Neuropsychiatric Association, Publisher American Psychiatric Publishing)

DOI

10.1176/appi.neuropsych.22.2.231

PMID

20463117

Abstract

The authors present preliminary results from a pilot study on patterns of brain injury associated with incident major depression after traumatic brain injury (TBI). Brain metabolite ratios, regional brain volumes, and cognitive performance were compared between 10 subjects with incident major depression post-TBI and seven TBI patients without major depression. TBI-depressed participants performed poorly on tests of frontotemporal functioning, had lower choline/creatine and N-acetylaspartate/creatine ratios in the right basal ganglia and had lower regional brain volumes in the right frontal, left occipital, and temporal lobes. The results suggest a possible role of frontotemporal lobe and basal ganglia pathology in depression after TBI.

Language: en