Citation

Bovbjerg VE, Siscovick DS, Psaty BM, McCann BS, Koepsell TD, Raghunathan TE, Wagner EH. J. Clin. Epidemiol. 1999; 52(12): 1197-1200.

Affiliation

Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA.

Copyright

(Copyright © 1999, Elsevier Publishing)

DOI

unavailable

PMID

10580782

Abstract

Meta-analyses of early primary prevention trials of lipid-lowering therapies suggested increased risk of injury deaths among treated persons. Our population-based case-control study examined the association of lipid-lowering medication use with fatal and nonfatal injuries in 298 cases and 332 controls. No increased injury risk was observed among current (OR = 0.46, 95% CI 0.18-1.21) or past users (OR = .92, 95% CI 0.44-1.95), after adjustment for behavioral disorders, medical conditions, and health status. Stratified analyses did not reveal sub-groups at significantly increased risk. These results, consistent with recent clinical trials and meta-analyses, suggest no increased injury risk associated with lipid-lowering medications.

Language: en