Citation

Jordan P, Brookes JG, Nikolic G, Le Couteur DG. J. Toxicol. Clin. Toxicol. 1999; 37(7): 861-864.

Affiliation

Canberra Hospital, Garran, Australia.

Copyright

(Copyright © 1999, Marcel Dekker)

DOI

unavailable

PMID

10630270

Abstract

BACKGROUND: The management and toxicokinetics of hydroxychloroquine overdose are poorly described. CASE REPORT: We report a case of an 18-year-old girl who ingested 20 g of hydroxychloroquine. She developed marked hypokalemia, hypotension, and ventricular tachyarrhythmias but survived with treatment including intubation, adrenaline infusion, high-dose diazepam, and aggressive potassium replacement. Plasma hydroxychloroquine level was 29.40 mumol/L (9.87 mg/L) 2 hours after ingestion and the elimination half-life of hydroxychloroquine was 22 hours. CONCLUSIONS: The clinical manifestations of this hydroxychloroquine overdose were similar to those reported for chloroquine overdose and the management principles recommended for chloroquine overdose appeared to be efficacious in this case.

Language: en