Citation

Holmes C, Smith H, Ganderton R, Arranz M, Collier D, Powell J, Lovestone S. J. Neurol. Neurosurg. Psychiatry 2001; 71(6): 777-779.

Affiliation

University of Southampton, Community Clinical Sciences Research Division, Memory Assessment and Research Centre, Moorgreen Hospital, Botley Road, West End, Southampton SO30 3JB, UK. ch4@soton.ac.uk

Copyright

(Copyright © 2001, BMJ Publishing Group)

DOI

unavailable

PMID

11723200

PMCID

PMC1737623

Abstract

This study investigated possible associations between selected polymorphisms in the dopamine receptor genes DRD1 and DRD3 with the presence of psychotic phenomena or aggressive behaviour in a community based cohort of 134 patients with late onset Alzheimer's disease. An association was found between the presence of psychotic symptoms and aggressive behaviour and the DRD1 polymorphism and between the presence of psychosis, but not aggression, and the DRD3 polymorphism. Specifically, carriers of the DRD1 B2 allele were more likely to be aggressive or experience hallucinations whereas homozygous carriers of the DRD3 1 allele were more likely to experience delusions.

Language: en