Citation

Val'dman EA. Eksp. Klin. Farmakol. 2000; 63(5): 3-6.

Vernacular Title

Farmakologicheskaia aktivnost' novogo proizvodnogo adamantana--potentsial'nogo

Affiliation

Laboratory of Psychopharmacology, Russian Academy of Medical Sciences, Moscow, Russia.

Copyright

(Copyright © 2000, Izo-Vo Meditsina)

DOI

unavailable

PMID

11109514

Abstract

The effect of a new potential antiparkinsonian drug, N-(2-adamantyl)hexamethyleneimine hydrochloride (A-7), upon some behavioral parameters was studied in rats after subchronic 14-day treatment. Also studied was the effect of abrupt termination of a prolonged (22-day) drug administration. The subchronic treatment with A-7 at a dose of 10, 20, or 40 mg/kg did not produce significant changes in coordination, explorative behavior, muscle tone, and aggression level. At the same time, the 14-day treatment with A-7 at a dose of 10 mg/kg increased the pain threshold; A-7 at a dose of 40 mg/kg (but not 10 or 20 mg/kg) increased the spontaneous motor activity. Upon abrupt termination of the drug administration after a prolonged treatment sensitivity of the test animals with respect to the MFTP neurotoxin as compared to that observed in the non-drug control group.

Language: ru