Citation

Labar G, Michaux C. Chem. Biodivers. 2007; 4(8): 1882-1902.

Copyright

(Copyright © 2007, Verlag Helvetica Chimica Acta AG, Zürich, Switzerland, Publisher John Wiley and Sons)

DOI

10.1002/cbdv.200790157

PMID

unavailable

Abstract

Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme within the amidase-signature family that terminates the action of several endogenous lipid messengers, including oleamide and the endocannabinoid anandamide. The hydrolysis of such messengers leads to molecules devoid of biological activity, and, therefore, modulates a number of neurobehavioral processes in mammals, including pain, sleep, feeding, and locomotor activity. Investigations into the structure and function of FAAH, its biological and therapeutic implications, as well as a description of different families of FAAH inhibitors are the topic of this review.