Citation

Ujike H. Nihon Arukoru Yakubutsu Igakkai Zasshi 2008; 43(2): 87-96.

Affiliation

Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.

Copyright

(Copyright © 2008, Japanese Medical Society of Alcohol and Drug Studies)

DOI

unavailable

PMID

18516948

Abstract

Predisposition to alcohol dependence is affected by multiple environmental and genetic factors in complicated way. Family and twin studies estimated about 60% of hereditary rate for alcoholism. Many lines of evidence by divergent methods, e.g. gene-manipulated animals, linkage of human genome and genetic association studies, are accumulating for molecular genetic components involved in alcoholism. These studies have shown that genetic polymorphisms of the genes encoding alcohol metabolism enzymes and neurotransmitter signaling molecules in dopamine, GABA, opioid and serotonin systems, were substantially involved in individual variation of susceptibility to alcohol dependence. Recent whole-genome association examination using 500K gene-chip revealed that a set of genes of adhesion and cytoarchitecture molecules were also involved in the disorder. These unexpected new findings by gene-chip technology, which need to be confirmed by case-control association one by one, must bring about breakthrough in investigation of neural mechanisms of alcohol dependence and innovative therapy.

Language: ja