Citation

Heiser JM, Daya MR, Magnussen AR, Norton RL, Spyker DA, Allen DW, Krasselt W. J. Toxicol. Clin. Toxicol. 1992; 30(2): 269-283.

Affiliation

Oregon Health Sciences University, Portland.

Copyright

(Copyright © 1992, Marcel Dekker)

DOI

unavailable

PMID

1588676

Abstract

A fatal case of strychnine intoxication is reported. The patient expired despite early aggressive management and prevention of metabolic complications. Serial blood levels are reported. In contrast to a previous report describing first order elimination kinetics, our data suggest that strychnine follows Michaelis-Menton elimination kinetics. The case illustrates the rapid, dramatic course of severe strychnine ingestions. A review of the toxicokinetics, mechanism of action and treatment of strychnine intoxication follows.

Language: en