Citation

Zotz RB, Mebs D, Hirche H, Paar D. Toxicon 1991; 29(12): 1501-1508.

Affiliation

Department of Medicine, University of Essen, F.R.G.

Copyright

(Copyright © 1991, Elsevier Publishing)

DOI

unavailable

PMID

1801326

Abstract

After a bite by the aglyphous red-necked keelback snake Rhabdophis subminiatus a complete defibrinogenation syndrome with severe hemorrhagic diathesis developed in a 25-year-old man. In vitro studies showed that the venom gland extract of the snake contains a very active prothrombin (Factor II) activator. The thrombin generated is inhibited neither by antithrombin III nor the antithrombin-III-heparin complex. The venom gland extract stimulated also the tissue plasminogen activator; however, it did not cause direct activation of plasminogen, protein C, Factor X or direct degradation of fibrinogen.

Language: en