Citation

Radulović N, Dorđević N, Denić M, Pinheiro MM, Fernandes PD, Boylan F. Food Chem. Toxicol. 2012; 50(2): 274-279.

Affiliation

Department of Chemistry, Faculty of Science and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia.

Copyright

(Copyright © 2012, Elsevier Publishing)

DOI

10.1016/j.fct.2011.10.060

PMID

22063758

Abstract

2-Pentylpiperidine, named conmaculatin, a novel volatile alkaloid related to coniine was identified from the renowned toxic weed Conium maculatum L. (Apiaceae). The structure of conmaculatin was corroborated by synthesis (8 steps starting from cyclohexanol, overall yield 12%). Conmaculatin's strong peripheral and central antinociceptive activity in mice was observed in a narrow dose range (10-20mg/kg). It was found to be lethal in doses higher than 20mg/kg.

Language: en