Citation

Hu C, Zhang A, Huang X. Zhonghua Yu Fang Yi Xue Za Zhi 2001; 35(1): 23-25.

Affiliation

Department of Public Health, Guiyang Medical College, Guiyang, 550004, China.

Copyright

(Copyright © 2001, Zhonghua yi xue hui)

DOI

unavailable

PMID

11860954

Abstract

OBJECTIVE: To study expression of P53mt protein in skin of patient with arseniasis caused by coal-burning. METHODS: According to pathological diagnosis, the patients were divided into carcinoma group (A group, 18 cases), pre-carcinoma group (B group 11 cases) and general pathological change group (C group, 39 cases). Immuno-histochemical technique of two steps was used to detect expression of P53 mt protein. RESULTS: Among A, B and C groups, the positive cell densities of P53mt protein were 38.07 +/- 29.00, 17.16 +/- 15.00 and 4.05 +/- 8.24 respectively, but no positive cell in normal group; there was statistical significance among A, B and C groups (A and C: P < 0.01, A and B: P < 0.01, B and C: P < 0.05); positive percentages of A, B and C groups were 88.89%, 72.73% and 25.64% (A and C: P < 0.01; B and C: P < 0.05), respectively, for difference of grade constitution, there was statistical significance (P < 0.01) among three groups; grade II and III made up 38.89% in A group, but 9.09% in B group and 2.56% in C group. CONCLUSIONS: P53mt gene play a certain role in the development of skin cancer from arseniasis caused by coal-burning; the detection of P53mt protein can show whether pathological changes of skin due to the disease is malignant or benign.

Language: zh