Citation

Zabrodskiĭ PF. Eksp. Klin. Farmakol. 1999; 62(3): 48-49.

Vernacular Title

Vliianie timogena na postintoksikatsionnoe immunodefitsitnoe sostoianie,

Affiliation

Department of Toxicology, Saratov State Medical University, Russia.

Copyright

(Copyright © 1999, Izo-Vo Meditsina)

DOI

unavailable

PMID

10439949

Abstract

It was demonstrated in experiments on Wistar rats that acute acetonitrile (AN) intoxication (0.8L D50) causes decrease of antibody-forming cells in the spleen, mainly those related to the T-dependent antigen, functioning of the natural cell-killers, antibody-dependent cytotoxicity, the ability of macrophages to induce the humoral immune responses and the delayed hypersensitivity reaction. Thymogen restored most of the humoral and cell immune reactions which were reduced by AN.

Language: ru