Citation

Gullotta F, Masi AD, Ascenzi P. IUBMB Life 2012; 64(5): 378-386.

Affiliation

Department of Biology and Interdepartmental Laboratory for Electron Microscopy, University Roma Tre, Roma, Italy.

Copyright

(Copyright © 2012, John Wiley and Sons)

DOI

10.1002/iub.1015

PMID

22431507

Abstract

The highly toxic gas carbon monoxide (CO) displays many physiological roles in several organs and tissues. Although many diseases, including cancer, hematological diseases, hypertension, heart failure, inflammation, sepsis, neurodegeneration, and sleep disorders, have been linked to abnormal endogenous CO metabolism and functions, CO administration has therapeutic potential in inflammation, sepsis, lung injury, cardiovascular diseases, transplantation, and cancer. Here, insights into the CO-based therapy, characterized by the induction or gene transfer of heme oxygenase-1 and either gas or CO-releasing molecule administration, are reviewed. 2012 IUBMB IUBMB Life, 2012.

Language: en