Citation

Lin NC, Lin JL, Lin-Tan DT, Yu CC. J. Toxicol. Clin. Toxicol. 2003; 41(6): 877-881.

Affiliation

Poison Center, Department of Internal Medicine, Chang Gung Memorial Hospital, Lin-Kou Medical Center, Chang Gung Medical College and University, Taipei, Taiwan, ROC.

Copyright

(Copyright © 2003, Marcel Dekker)

DOI

unavailable

PMID

14677801

Abstract

The article presents a patient with severe paraquat poisoning from dermal exposure, who had chemical bums to more than 10% of his body surface area, serum paraquat level 0.13 microg/mL 60 hr after exposure, and severe hypoxemia (PaO2 41.6 mmHg). The patient was successfully treated with combined initial megadoses of cyclophosphamide (15 mg/kg/day, total 2 days) with repeated methylprednisolone pulse therapy (15 mg/kg/day, total 6 days) and continuous dexamethasone administration (5 mg every 8 hr), and recovered completely without sequelae 3 months later. This treatment deserves further investigation in future clinical trials.

Language: en