Citation

Asadullina NR, Usacheva AM, Gudkov SV. J. Radiat. Res. (Tokyo) 2012; 53(2): 211-216.

Affiliation

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences.

Copyright

(Copyright © 2012, Japan Radiation Research Society, Publisher Oxford University Press)

DOI

unavailable

PMID

22510593

Abstract

The aim of the present study was to investigate the radiation modulating properties of inosine-5'-monophosphate (IMP). Mice injected introperitoneally (i.p.) with IMP 15 minutes after irradiation with a lethal irradiation dose of 7 Gy have better survival rates comparative to irradiated mice non treated with IMP. The dose reduction factor of the IMP is 1.22. Using a hematologdical test we demonstrated that administration of IMP alleviates the symptoms of radiation-induced leukopenia and thrombocytopenia. The DNA damage in bone marrow and thymus cells of irradiated mice was measured by flow cytofluorometry and micronucleus test (MN-test). The tests show that i.p. administration of IMP to irradiated animals leads to a significant reduction of the DNA damage level. In this paper we show that IMP substantially modulates the damaging effects of ionizing radiation protecting irradiated mice and it is a promising agent for a treatment of leukopenia.

Language: en