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Citation |
Saggiomo SL, Seymour JE. Toxicon 2012; 60(3): 391-395. |
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Affiliation |
School of Marine and Tropical Biology, James Cook University, PO Box 6811, Cairns, QLD 4870, Australia. |
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Copyright |
(Copyright © 2012, Elsevier Publishing) |
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DOI |
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PMID |
22560886 |
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Abstract |
An investigation into the cardiotoxic effects in human cardiomyocytes of different fractions (as produced from an FPLC) of the venom from Chironex fleckeri showed that whole venom caused cardiac cell death in minutes, measured as cell detachment using xCELLigence technology. However, only one fraction of the venom was responsible for this effect. When all extracted venoms were recombined a similar result was seen for the toxic fraction, however these effects where slower than unfractionated venom alone even though the concentrations were similar. The difference in the results between fractioned and unfractionated venom may have been caused by compounds remaining in the FPLC column, which may interact with the toxic fraction to cause rapid cell detachment or death. Language: en |