Citation

Ren P, Guan DW, Zhao R, Ma WX, Zhang ST. Fa Yi Xue Za Zhi 2012; 28(2): 92-4, 99.

Affiliation

Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110001, China.

Copyright

(Copyright © 2012, Si fa bu Si fa jian ding ke xue ji shu yan jiu suo)

DOI

unavailable

PMID

22619801

Abstract

OBJECTIVE: To establish the model of skin scald in mice for the study of skin thermal injuries. METHODS: After anaesthetization mice were scalded in a 1 cm-diameter circle area on the central dorsum by boiling water at contact times: 10s or 25s. The mice were sacrificed at 1, 3, 5, 7 and 10 days after scald. The skin samples were collected and analyzed by gross and histopathological examinations. RESULTS: Deep II degree thermal injury involving full-thickness skin was observed in the 10s scald group. III degree thermal injury involving full-thickness skin and the dorsal skeletal muscle was observed in the 25 s scald group. CONCLUSION: A mouse skin scald model is established which is stable and can be used on the skin thermal injury in future research.

Language: zh