Citation

Dale GE, Leigh PN, Luthert P, Anderton BH, Roberts GW. J. Neurol. Neurosurg. Psychiatry 1991; 54(2): 116-118.

Affiliation

Department of Immunology, St. George's Hospital Medical School, London, UK.

Copyright

(Copyright © 1991, BMJ Publishing Group)

DOI

unavailable

PMID

1850450

PMCID

PMC1014344

Abstract

Ubiquitin, a protein thought to be involved in the ATP-dependent non-lysosomal degradation of abnormal proteins, has already been identified as a component of neurofibrillary tangles in Alzheimer's disease. We have examined ubiquitin immunoreactivity in a unique collection of brains from 16 ex-boxers including 11 with dementia pugilistica. Neurofibrillary tangles of dementia pugilistica were labelled with an affinity purified antiserum to ubiquitin, and BF10, a monoclonal antibody to a neurofilament epitope.

Language: en