Citation

Ritschel WA, Erni W. Int. J. Clin. Pharmacol. Biopharm. 1977; 15(4): 172-175.

Copyright

(Copyright © 1977, Urban Und Schwarzenberg)

DOI

unavailable

PMID

858649

Abstract

The influence of the temperature of ingested water on the stomach emptying time of solid material was studied in healthy volunteers using a telemetric pH measurement device. The time of discharge of the indigestible capsule from the stomach into the duodenum is statistically faster when administered with 250 ml of water at 5 degrees C, 15.91+/-10.04 min. (mean+/-SD) than it is with water at 20-25 degrees C, 48.18+/-28.97 min (mean+/-SD) or at 45 degrees C 71.42+/-37.08 min. (mean+/-SD). It seems that the interindividual variation is larger than the intra-individual one. These observations suggest that enteric coated preparations and drugs which are inactivated by gastric fluid or irritate gastric mucosa should be administered only with ice water (4-6 degrees C), and stomach washings (with charcoal) in order to remove a poisoning agent should be performed with warm water (45 degrees C).

Language: en