Citation

Casali L, Pozzi E, Rampulla C, Serra R. Int. J. Clin. Pharmacol. Biopharm. 1977; 15(10): 480-484.

Copyright

(Copyright © 1977, Urban Und Schwarzenberg)

DOI

unavailable

PMID

924703

Abstract

The authors investigated, in 22 normal subjects and 22 bronchopneumopathic patients, the action of two anxiolytic drugs on ventilatory function and on the associated respiratory function. The analyses carried out before drug administration and 1, 2, 6 hours later showed that while a drug did not cause any important variation in the ventilatory parameters and O2 uptake, both in healthy subjects and in patients, the second one clearly reduced the ventilatory efficacy and O2 uptake. This behavior was quite evident 1 and 2 hours after the assumption of the drug while after 6 hours the parameters returned to the initial values. The influence of the circadian rhythm after 6 hours was more evident in both groups after the assumption of the second anxyolitic drug than with the first. Furthermore, evaluation drawn up among the healthy subjects, during simulated driving tests, demonstrated that the second anxyolytic drug provoked a standard depression unevenly distributed like that obtained after the ingestion of a fixed dose of an alcoholic drink.

Language: en