Citation

Angoa-Pérez M, Kane MJ, Briggs DI, Herrera-Mundo N, Viano DC, Kuhn DM. J. Neurochem. 2014; 129(6): 916-931.

Affiliation

Research & Development Service, John D. Dingell VA Medical Center, 4646 John R, Detroit, Michigan, 48201, USA; Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Tolan Park Medical Building, 3901 Chrysler Drive, Detroit, Michigan, 48201, USA.

Copyright

(Copyright © 2014, John Wiley and Sons)

DOI

10.1111/jnc.12690

PMID

24673291

Abstract

Sports-related head impact and injury has become a very highly contentious public health and medico-legal issue. Near-daily news accounts describe the travails of concussed athletes as they struggle with depression, sleep disorders, mood swings and cognitive problems. Some of these individuals have developed chronic traumatic encephalopathy, a progressive and debilitating neurodegenerative disorder. Animal models have always been an integral part of the study of traumatic brain injury in humans but, historically, they have concentrated on acute, severe brain injuries. This review will describe a small number of new and emerging animal models of sports-related head injury that have the potential to increase our understanding of how multiple mild head impacts, starting in adolescence, can have serious psychiatric, cognitive and histopathological outcomes much later in life. This article is protected by copyright. All rights reserved.

Language: en